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Electronic Lab Notebook
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RSV Multiplex Evaluation
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Extraction_Protocol_v3.docx
Validation_Metrics.xlsxBackground
Respiratory syncytial virus (RSV) remains a leading cause of acute lower respiratory tract infection in infants and older adults. With the recent FDA approval of nirsevimab (Beyfortus) and the Arexvy vaccine, accurate genotyping of circulating RSV strains is increasingly important for surveillance and therapeutic resistance monitoring.
This experiment evaluates a multiplex whole-genome sequencing approach for simultaneous detection and subtyping of RSV-A and RSV-B from clinical nasopharyngeal specimens. The assay targets all 10 genes across the ~15.2 kb RSV genome using tiled amplicon primers designed against the A/ON1 (GenBank KJ723482) and B/BA9 (GenBank MG642064) reference lineages.
Library preparation follows the SOP-MOL-2025-042 protocol using the Illumina DNA Prep Kit (Cat# 20060059, Lot# 2503847, Exp: 2026-08) with unique dual indexing. Sequencing is performed on the NextSeq 550 (SN: NB502104) using a 300-cycle Mid Output v2.5 kit targeting ≥1,000x mean coverage depth per amplicon.
The records for how to calibrate the freezer can be found in @"Compliance & Quality Management System".
Cross-Reference Anything
21 CFR Part 11 Signatures
R&D AI Assistant
Key Features
Our electronic lab notebook modernizes laboratory operations with powerful features designed for today's research needs
Comprehensive Data Capture
Record, organize, and standardize all your experimental data in one secure platform.
- Support for text, tables, attachments, and structured data
- Integrated digital workflows with built-in templates
- Direct instrument data integration capabilities
- Streamlined documentation for compliance
Seamless Collaboration
Enable real-time team collaboration while maintaining data integrity and security.
- Multi-user access with granular permission controls
- Version history and change tracking
- Commenting and discussion threads
- Secure sharing with external collaborators
Regulatory Compliance
Meet stringent regulatory requirements with built-in compliance features.
- 21 CFR Part 11 compliance with electronic signatures
- Complete audit trails for all data modifications
- Timestamped entries with digital authentication
- Customizable workflows for GLP/GMP environments
Advanced Search & Analytics
Quickly find and analyze experimental data across your entire organization.
- Full-text search across all notebook entries
- Structured metadata filtering and tagging
- Cross-project data mining capabilities
- Custom reporting and visualization tools
R&D AI Assistant
A PhD-level scientific AI embedded directly in your notebook. It draws on your inventory, your instruments, and your experiments, giving you faster, better-informed decisions at the bench.
Context-Aware Intelligence
The R&D Assistant connects to your live lab data rather than working in isolation. It cross-references instruments with reagent compatibility, verifies lot expiration status, and identifies gaps in materials or equipment before you have to ask.
Checks stock levels, lot numbers, and expiration dates in real time
Verifies PM status, calibration records, and platform compatibility
Reads your protocols, audit trails, and linked references for full context
Searches your lab's catalog for methodology, CPT codes, and regulatory status
Generate Validation Plans
Describe an assay and the assistant builds a structured validation plan, drawing on your actual instruments and available reagents while flagging what needs to be ordered. It applies CLIA, CAP, and ISO 15189 criteria automatically.
Analyze Experimental Data
Upload a CSV or Excel file and the assistant runs the statistics: CV%, bias, linearity, method comparison, and Westgard rule evaluation. It interprets the results against your acceptance criteria rather than reporting raw figures alone.
Search & Cite Literature
Query PubMed and bioRxiv directly from your notebook. The assistant enriches searches with your experiment context, ranks results by relevance, and saves citations to your experiment record.
Review & Audit Readiness
Ask the assistant to review a plan or experiment. It checks reagent qualification, equipment calibration status, missing controls, statistical adequacy, and documentation completeness against 21 CFR Part 11 and CAP standards.
Build Presentations
Compile experiment data, audit trails, and results into structured presentations for team reviews, regulatory submissions, or stakeholder updates, all within the notebook.
Seamless Integration
Our electronic lab notebook platform connects with other AminoCloud systems and workflows
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